che wei hsu cover photo

Che-Wei Hsu

Born and raised in Taichung, Taiwan, I earned my B.S. in Biochemistry and M.S. in Agronomy from National Taiwan University before completing my Ph.D. in Developmental Biology and Bioinformatics in Ohler lab at MDC-BIMSB (Berlin, Germany). There, I led construction of one of the most comprehensively annotated single-cell atlases of a plant organ (Developmental Cell 2022, cover), now a community reference with over 400 citations, and developed COPILOT, a biology-informed quality-control algorithm for single-cell data.

In 2023 I joined Philip Benfey’s lab at Duke as a postdoc, where I mapped brassinosteroid gene regulatory networks at cellular resolution (Science 2023), led the single-cell analyses behind a polarity-guided mitotic division mechanism that tunes hormone signaling (Cell 2025), and built a rice root atlas that revealed how root tissues adapt to soil compaction (Nature 2025). 

I am now a Resnick Sustainability Institute Pioneer Postdoctoral Fellow in Trevor Nolan’s lab at Caltech, where I lead 3D profiling of cellular morphogenesis and spatial transcriptomic analysis of Arabidopsis roots: the PHYTOMap computational pipeline, the Virtual Root initiative, single-cell analyses of osmotic stress and in vivo Perturb-seq, and a 480-probe Xenium spatial panel. My research asks how individual cells coordinate their developmental programs to build a resilient organism, and how they adjust when the environment changes.

Education

Education is the comprehensive process of acquiring knowledge, developing skills, and shaping one’s intellectual, moral and social character to prepare for life and contribute to society

Humboldt University (Humboldt Universität zu Berlin)                                         2019 – 2022

Ph.D. in Developmental Biology and Bioinformatics

National Taiwan University                                                                                            2016 – 2018

M.S. in Agronomy, Crop Division

National Taiwan University                                                                                             2012 – 2016

B.S. in Biochemistry

10+ years of research

A long-term commitment to advancing plant systems and computational biology toward resilient agriculture

10+

Publications

10+

Conferences

10+

Paper reviews

7+

Mentees